Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop

被引：9

作者：

Van Etten, Richard A. ^{[1
]}

Mauro, Michael ^{[2
]}

Radich, Jerald P. ^{[3
]}

Goldman, John M. ^{[4
]}

Saglio, Giuseppe ^{[5
]}

Jamieson, Catriona ^{[6
]}

Soverini, Simona ^{[7
]}

Gambacorti-Passerini, Carlo ^{[8
]}

Hehlmann, Ruediger ^{[9
]}

Martinelli, Giovanni ^{[7
]}

Perrotti, Danilo ^{[10
]}

Scadden, David T. ^{[11
,12
]}

Skorski, Tomasz ^{[13
]}

Tefferi, Ayalew ^{[14
]}

Mughal, Tariq I. ^{[15
]}

机构：

[1] Tufts Med Ctr, Boston, MA 02111 USA

[2] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[3] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[4] Univ London Imperial Coll Sci Technol & Med, London, England

[5] Univ Turin, Orbassano, Italy

[6] Univ Calif San Diego, La Jolla, CA 92093 USA

[7] Univ Bologna, Bologna, Italy

[8] Univ Monza, Monza, Italy

[9] Univ Mannheim, D-68131 Mannheim, Germany

[10] Ohio State Univ, Columbus, OH 43210 USA

[11] Massachusetts Gen Hosp, Boston, MA 02114 USA

[12] Harvard Univ, Sch Med, Boston, MA USA

[13] Temple Univ, Philadelphia, PA 19122 USA

[14] Mayo Clin, Rochester, MN USA

[15] Univ Colorado, Denver, CO 80202 USA

来源：

LEUKEMIA & LYMPHOMA | 2013年 / 54卷 / 06期

关键词：

Chronic myelogenous leukemia; dasatinib; imatinib mesylate; nilotinib; tyrosine kinase inhibitor; DIAGNOSED CHRONIC-PHASE; BCR-ABL EXPRESSION; TYROSINE KINASE; STEM-CELLS; FOLLOW-UP; T315I MUTANT; IMATINIB; BCR-ABL1; NILOTINIB; INHIBITION;

D O I：

10.3109/10428194.2012.745524

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Following the 53rd annual meeting of the American Society of Hematology (ASH) in San Diego in December 2011, a group of clinical and laboratory investigators convened for the 6th Post-ASH International Workshop on Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN). The Workshop took place on 13-14 December at the Estancia, La Jolla, California, USA. This report summarizes the most recent advances in the biology and therapy of CML that were presented at the ASH meeting and discussed at the Workshop. Preclinical studies focused on the CML stem cell and its niche, and on early results of deep sequencing of CML genomes. Clinical advances include updates on second- and third-generation tyrosine kinase inhibitors (TKIs), molecular monitoring, TKI discontinuation studies and new therapeutic agents. A report summarizing the pertinent advances in MPN has been published separately.

引用

页码：1151 / 1158

页数：8

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