Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

被引：116

作者：

Dongiovanni, Paola ^{[1
]}

Romeo, Stefano ^{[2
,3
]}

Valenti, Luca ^{[1
,4
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Internal Med & Metab Dis, I-20122 Milan, Italy

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Wallenberg Lab, S-40530 Gothenburg, Sweden

[3] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Clin Nutr Unit, I-88100 Catanzaro, Italy

[4] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

GREATER-THAN-G; TRANSPORT PROTEIN 5; HEPATIC STEATOSIS; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; I148M POLYMORPHISM; ADIPOSE-TISSUE; OBESE CHILDREN; CONFERS SUSCEPTIBILITY; HISTOLOGICAL SEVERITY;

D O I：

10.1155/2015/460190

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Liver fat accumulation generally related to systemic insulin resistance characterizes nonalcoholic fatty liver disease (NAFLD), which in the presence of nonalcoholic steatohepatitis (NASH) can progress towards cirrhosis and hepatocellular carcinoma. Due to the epidemic of obesity, NAFLD is now the most frequent liver disease in Western countries. Epidemiological, familial, and twin studies provide evidence for a strong genetic component of NAFLD susceptibility. Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH. In this review, we aimed to provide an overview of recent insights into the genetics of hepatic fat accumulation and steatohepatitis.

引用

页数：10

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