Genome-wide approaches to identifying genetic factors in host susceptibility to tuberculosis

被引：35

作者：

Bellamy, Richard ^{[1
]}

机构：

[1] James Cook Univ Hosp, Dept Infect & Travel Med, Middlesbrough TS4 3BW, Cleveland, England

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 04期

关键词：

tuberculosis; linkage; genome-screen; slc11a1; NRAMP1;

D O I：

10.1016/j.micinf.2005.10.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host genetic factors are important in determining susceptibility to Mycobacterium tuberculosis. Genome-wide linkage studies have been performed in humans and in murine models of tuberculosis susceptibility. These studies have identified several important candidate loci for susceptibility to tuberculosis. This is an important step in resolving the complex etiology of the disease. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：1119 / 1123

页数：5

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