Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats

被引:53
作者
Modi, Ketan [1 ]
Santani, D. D. [1 ]
Goyal, R. K. [1 ]
Bhatt, P. A. [1 ]
机构
[1] LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, Gujarat, India
关键词
coenzyme Q10; diabetes mellitus; antioxidant activity; insulin resistance;
D O I
10.1385/BTER:109:1:025
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although coenzyme Q10 (CoQ10) is a component of the oxidative phosphorylation process in mitochondria that converts the energy in carbohydrates and fatty acids into ATP to drive cellular machinery and synthesis, its effect in type 1 diabetes is not clear. We have studied the effect of 4 wk of treatment with CoQ10 (10 mg/kg, ip, daily) in streptozotocin (STZ)-induced (40 mg/kg, iv in adult rats) type 1 diabetes rat models. Treatment with CoQ10 produced a significant decrease in elevated levels of glucose, cholesterol, triglycerides, very-low-density lipoprotein, low-density lipoprotein, and atherogenic index and increased high-density lipoprotein cholesterol levels in diabetic rats. CoQ10 treatment significantly decreased the area under the curve over 120 min for glucose in diabetic rats, without affecting serum insulin levels and the area under the curve over 120 min for insulin in diabetic rats. CoQ10 treatment also reduced lipid peroxidation and increased antioxidant parameters like superoxide dismutase, catalase, and glutathione in the liver homogenates of diabetic rats. CoQ10 also lowered the elevated blood pressure in diabetic rats. In conclusion, CoQ10 treatment significantly improved deranged carbohydrate and lipid metabolism of experimental chemically induced diabetes in rats. The mechanism of its beneficial effect appears to be its antioxidant property.
引用
收藏
页码:25 / 33
页数:9
相关论文
共 28 条
[1]  
AEBI H, 1984, METHOD ENZYMOL, V105, P121
[2]  
[Anonymous], 1991, OXIDATIVE STRESS OXI
[3]   EFFECT OF SODIUM NITRITE ON RED CELL GSH [J].
BEUTLER, E ;
KELLY, BM .
EXPERIENTIA, 1963, 19 (02) :96-&
[4]   Negative consequences of glycation [J].
Brownlee, M .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2000, 49 (02) :9-13
[5]   Biochemistry and molecular cell biology of diabetic complications [J].
Brownlee, M .
NATURE, 2001, 414 (6865) :813-820
[6]   BIOCHEMICAL, PHYSIOLOGICAL AND MEDICAL ASPECTS OF UBIQUINONE FUNCTION [J].
ERNSTER, L ;
DALLNER, G .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1995, 1271 (01) :195-204
[7]   THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].
ESTERBAUER, H ;
GEBICKI, J ;
PUHL, H ;
JURGENS, G .
FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390
[8]   DIABETES-MELLITUS, HYPERTENSION, AND CARDIOVASCULAR-DISEASE - WHICH ROLE FOR OXIDATIVE STRESS [J].
GIUGLIANO, D ;
CERIELLO, A ;
PAOLISSO, G .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1995, 44 (03) :363-368
[9]  
Kucharská J, 2000, PHYSIOL RES, V49, P411
[10]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265