Nickel-catalyzed tandem coupling of alpha,beta-enones, alkynes, and alkynyltins for the regio- and stereoselective synthesis of conjugated enynes

被引：46

作者：

Ikeda, S

Kondo, K

Sato, Y

机构：

[1] Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 23期

关键词：

D O I：

10.1021/jo961236h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nickel-catalyzed reaction of alpha,beta-enones 2 with alkynes 1, alkynyltins 6, and Me(3)SiCl was carried out by. the successive construction of two carbon-carbon bonds to give enol silyl ethers 5, which were then hydrolyzed to conjugated enynes 7, with high regio- and stereoselectivities (isomeric purities: 92-98%).

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页码：8248 / 8255

页数：8

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