Delineation of the native basin in continuum models of proteins

被引：7

作者：

Li, MS ^{[1
]}

Cieplak, M ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland

来源：

JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL | 1999年 / 32卷 / 30期

关键词：

D O I：

10.1088/0305-4470/32/30/305

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We propose two approaches for determining the native basins in off-lattice models of proteins. The first of them is based on exploring the saddle points on selected trajectories emerging from the native state. In the second approach, the basin size can be determined by monitoring random distortions in the shape of the protein around the native state. Both techniques yield similar results. As a byproduct, a simple method to determine the folding temperature is obtained.

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页码：5577 / 5584

页数：8

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