Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7

被引：8

作者：

Franti, M ^{[1
]}

Aubin, JT ^{[1
]}

Gautheret-Dejean, A ^{[1
]}

Malet, I ^{[1
]}

Cahour, A ^{[1
]}

Huraux, JM ^{[1
]}

Agut, H ^{[1
]}

机构：

[1] Hop La Pitie Salpetriere, Virol Lab, CERVI, UPRES EA 2387, F-75651 Paris 13, France

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 11期

关键词：

D O I：

10.1128/JVI.73.11.9655-9658.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.

引用

页码：9655 / 9658

页数：4

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