Ability of S100B to predict severity and cranial CT results in children with TBI

被引:32
作者
Babcock, Lynn [1 ,2 ]
Byczkowski, Terri [1 ]
Mookerjee, Sohug [2 ]
Bazarian, Jeffrey J. [2 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Pediat Emergency Med, Cincinnati, OH 45229 USA
[2] Univ Rochester, Med Ctr, Dept Emergency Med, Rochester, NY 14642 USA
关键词
Traumatic brain injury; cranial computed tomography; serum markers; emergency department; TRAUMATIC BRAIN-INJURY; MINOR HEAD-INJURY; NEURON-SPECIFIC ENOLASE; COMPUTED-TOMOGRAPHY; SERUM-LEVELS; NEUROBIOCHEMICAL MARKERS; PEDIATRIC-PATIENTS; PROTEIN; S-100B; DAMAGE;
D O I
10.3109/02699052.2012.694565
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objectives: To evaluate the ability of S100B to predict severity of TBI and abnormal cranial CT results for children with TBI. Methods: This is a secondary analysis of a previously established cohort of consecutive patients presenting to the emergency department with TBI limited to children <19 years of age, who arrived within 6 hours of injury, received a cranial CT scan and consented to blood drawn for S100B. Results: A total of 109 children were included in this cohort. The mean S100B levels were higher in children with moderate/severe TBI as compared to children with mild TBI based GCS score (0.281 mu gL(-1), 95% CI = 0.101, 0.461 vs 0.053, 95% CI = 0.010, 0.095). S100B levels were significantly elevated in children following TBI with abnormal cranial CT as compared to children with a normal cranial CT (0.210 mu gL(-1), SD = 0.313 vs 0.036 mu gL(-1), SD = 0.046, p = 0.03). Area under the curve for S100B was also significant (0.72, 95% CI = 0.58, 0.86) for prediction of abnormal cranial CT for children with TBI. S100B did not predict abnormal cranial CT for children following TBI with a GCS of 15 (AUC = 0.53, 95% CI = 0.36, 0.71). Conclusions: For children following TBI, S100B appears to predict severity of TBI; however, it may not be clinically useful as an independent screening test to select children with mild TBI who need a cranial CT.
引用
收藏
页码:1372 / 1380
页数:9
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