Low-frequency repetitive transcranial magnetic stimulation for the treatment of refractory partial epilepsy: A controlled clinical study

被引：137

作者：

Sun, Wei ^{[1
]}

Mao, Wei ^{[1
]}

Meng, Xianghong ^{[1
]}

Wang, Dequan ^{[1
]}

Qiao, Liang ^{[2
]}

Tao, Wei ^{[2
]}

Li, Liping ^{[1
]}

Jia, Xiaoying ^{[1
]}

Han, Chunyu ^{[1
]}

Fu, Mengmeng ^{[1
]}

Tong, Xiaoyan ^{[1
]}

Wu, Xun ^{[1
]}

Wang, Yuping ^{[1
]}

机构：

[1] Capital Med Univ, Dept Neurol, Xuan Wu Hosp, Beijing 100053, Peoples R China

[2] Capital Med Univ, Dept Funct Neurosurg, Xuan Wu Hosp, Beijing 100053, Peoples R China

来源：

EPILEPSIA | 2012年 / 53卷 / 10期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Low-frequency; High; low intensity; Repetitive transcranial magnetic stimulation; Refractory partial epilepsy; Seizures; Electroencephalogram; SEIZURE SUPPRESSION; CORTEX EXCITABILITY; EEG;

D O I：

10.1111/j.1528-1167.2012.03626.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: This study was designed to evaluate the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with refractory partial epilepsy. Methods: Sixty-four patients with refractory focal epilepsy were screened and 60 patients were randomly divided into two groups by stimulation intensity: 90% (group 1) or 20% (group 2) of resting motor threshold (rMT). Seizure frequency and interictal EEG epileptic discharges were compared between the baseline and follow-up periods. Key Findings: Seizures significantly decreased following 2-weeks high intensity (90% rMT) rTMS treatment compared with baseline level (p < 0.05). rTMS also decreased interictal epilepsy discharges and improved the scales of Symptom Checklist-90 significantly (p < 0.05). Seizures and spikes in the follow-up period in the patients who received low intensity (20% rMT) rTMS did not show any difference compared with baseline data (p > 0.05, respectively). Significance: Low-frequency high intensity rTMS (90% rMT) delivered into the epileptogenic zone had a significant antiepileptic effect on patients with refractory partial seizures. rTMS treatment can also reduce the interictal epileptic discharge frequency and improve the psychological condition of these patients.

引用

页码：1782 / 1789

页数：8

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