A new approach to the inhibition of gene expression

被引：27

作者：

Caplen, NJ ^{[1
]}

机构：

[1] NIH, NHGRI, Med Genet Branch, Bethesda, MD 20892 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2002年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(01)01900-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The induction of a specific down-regulation in gene expression is an important research tool. Recently, several related processes including post-transcriptional gene silencing (PTGS) and RNA interference (RNAi) have been identified that generate sequence-specific inhibition of gene expression. Although the physiological function of PTGS and RNAi is still being elucidated, these pathways have been used to rapidly determine gene function. The recent observation of RNAi in mammalian cells extends the possible applications of these mechanisms.

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页码：49 / 51

页数：3

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