Whole genome amplification - applications and advances

被引：70

作者：

Hawkins, TL ^{[1
]}

Detter, JC ^{[1
]}

Richardson, PM ^{[1
]}

机构：

[1] Lawrence Berkeley Lab, US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(02)00286-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of whole genome amplification is something that has arisen in the past few years as the polymerase chain reaction (PCR) has been adapted to replicate regions of genomes that are of biological interest. The applications are many - forensic science, embryonic disease diagnosis, bioterrorism genome detection, 'immortalization' of clinical samples, microbial diversity, and genotyping. Several recent papers suggest that whole genomes can be replicated without bias or non-random distribution of the target, these findings open up a new avenue to molecular biology.

引用

页码：65 / 67

页数：3

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