G protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus

被引：31

作者：

Morishige, K

Inanobe, A

Takahashi, N

Yoshimoto, Y

Kurachi, H

Miyake, A

Tokunaga, Y

Maeda, T

Kurachi, Y

机构：

[1] OSAKA UNIV,FAC MED,DEPT PHARMACOL 2,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,FAC MED,DEPT OBSTET & GYNECOL,SUITA,OSAKA 565,JAPAN

[3] YAMAGATA UNIV,SCH MED,DEPT CELL BIOL & SIGNALLING,YAMAGATA 99023,JAPAN

[4] SHIGA UNIV MED SCI,DEPT ANAT 1,SHIGA 52021,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0400

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (K-G) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in thr presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activation of the K-G channel may underlie presynaptic inhibition of neurotransmitter release by various agonists, such as dopamine, noradrenaline, opioids, and histamine, in PVN. (C) 1996 Academic Press, Inc.

引用

页码：300 / 305

页数：6

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