Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

被引：203

作者：

Glinel, Karine ^{[1
,2
]}

Jonas, Alain M. ^{[1
,3
]}

Jouenne, Thierry ^{[2
]}

Leprince, Jerome ^{[4
]}

Galas, Ludovic ^{[4
]}

Huck, Wilhelm T. S. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Melville Lab Polymer Synth, Cambridge CB2 1EW, England

[2] Univ Rouen, CNRS, FRE 3101, Lab Polymeres, F-76821 Mont St Aignan, France

[3] Catholic Univ Louvain, Res Ctr Micro & Nanoscop Mat & Devices CeRMiN, B-1348 Louvain, Belgium

[4] Univ Rouen, INSERM, U413, F-76821 Mont St Aignan, France

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 01期

关键词：

SELF-ASSEMBLED MONOLAYERS; POLY(ETHYLENE GLYCOL); MICROBIAL ADHESION; BACTERIAL BIOFILMS; ADSORPTION; MAGAININS; PROTEINS; RESIST; HOST; CELL;

D O I：

10.1021/bc800280u

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.

引用

页码：71 / 77

页数：7

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