Fiber-derived butyrate and the prevention of colon cancer

被引：81

作者：

Hassig, CA ^{[1
]}

Tong, JK ^{[1
]}

Schreiber, SL ^{[1
]}

机构：

[1] HARVARD UNIV, DEPT CELLULAR & MOL BIOL, HOWARD HUGHES MED INST, CAMBRIDGE, MA 02138 USA

来源：

CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 11期

关键词：

D O I：

10.1016/S1074-5521(97)90111-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a smali-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.

引用

页码：783 / 789

页数：7

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