Chronic alcohol consumption causes accelerated myocardial preconditioning to ischemia-reperfusion injury

被引:14
作者
McDonough, KH
机构
[1] Department of Physiology, Louisiana State University, Medical Center, New Orleans, LA 70112
关键词
reperfusion; sepsis; rat;
D O I
10.1111/j.1530-0277.1997.tb03851.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
We have previously demonstrated that chronic alcohol consumption (8 to 10 weeks with ethanol as 36% of the caloric intake) does not exacerbate the effects of ischemia reperfusion injury on the heart. In those same studies, however, Gram-negative sepsis caused myocardial depression in both control and alcoholic rats, but also protected hearts from further damage due to ischemia-reperfusion. In the present study, we determined if preconditioning, a very short ischemia-reperfusion episode that protects the heart from more prolonged ischemia, would have similar effects on hearts from alcoholic and control rats with or without sepsis. Thus, rats were fed a liquid diet supplemented with ethanol or dextrin for 8 to 10 weeks, Some alcoholic and control rats were made septic with Escherichia coli injected into the subcutaneous space, whereas others received an injection of sterile saline. Isolated, isovolumically beating hearts were studied the following day. Hearts were made ischemic for 5 min, reperfused for 5 min, and then made ischemic for 35 min and reperfused for 25 min, Data from similar groups of hearts receiving only 35 min ischemia, and studied at the same time as the present groups, have been previously reported, The 5-min preconditioning episode was more effective in protecting hearts in the alcohol group than in the control group, Postischemic left ventricular developed pressure and +dP/dt(max) were not significantly decreased from the preischemic values in the alcohol group, but were significantly decreased in the control group, The time to recovery of spontaneous contractions was decreased by preconditioning in the alcohol group but not in the control group, and the recovery of coronary flow was enhanced in the alcohol group, but not in the control group by preconditioning, Thus a single 5-min ischemic procedure was effective in protecting the heart from prolonged ischemia in the alcohol group, whereas it was not sufficient to elicit protection in the control group. Sepsis depressed preischemic function in both groups, but recovery from ischemia was complete.
引用
收藏
页码:869 / 873
页数:5
相关论文
共 28 条
[1]   ISCHEMIC PRECONDITIONING ATTENUATES ACIDOSIS AND POSTISCHEMIC DYSFUNCTION IN ISOLATED RAT-HEART [J].
ASIMAKIS, GK ;
INNERSMCBRIDE, K ;
MEDELLIN, G ;
CONTI, VR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (03) :H887-H894
[2]   PRECONDITIONING AGAINST MYOCARDIAL DYSFUNCTION AFTER ISCHEMIA AND REPERFUSION BY AN ALPHA-1-ADRENERGIC MECHANISM [J].
BANERJEE, A ;
LOCKEWINTER, C ;
ROGERS, KB ;
MITCHELL, MB ;
BREW, EC ;
CAIRNS, CB ;
BENSARD, DD ;
HARKEN, AH .
CIRCULATION RESEARCH, 1993, 73 (04) :656-670
[3]   NEUTROPHILS CONTRIBUTE TO TNF INDUCED MYOCARDIAL TOLERANCE TO ISCHEMIA [J].
BROWN, JM ;
ANDERSON, BO ;
REPINE, JE ;
SHANLEY, PF ;
WHITE, CW ;
GROSSO, MA ;
BANERJEE, A ;
BENSARD, DD ;
HARKEN, AH .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992, 24 (05) :485-495
[4]   INTERLEUKIN-1 PRETREATMENT DECREASES ISCHEMIA REPERFUSION INJURY [J].
BROWN, JM ;
WHITE, CW ;
TERADA, LS ;
GROSSO, MA ;
SHANLEY, PF ;
MULVIN, DW ;
BANERJEE, A ;
WHITMAN, GJR ;
HARKEN, AH ;
REPINE, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5026-5030
[5]   ENDOTOXIN PRETREATMENT INCREASES ENDOGENOUS MYOCARDIAL CATALASE ACTIVITY AND DECREASES ISCHEMIA REPERFUSION INJURY OF ISOLATED RAT HEARTS [J].
BROWN, JM ;
GROSSO, MA ;
TERADA, LS ;
WHITMAN, GJR ;
BANERJEE, A ;
WHITE, CW ;
HARKEN, AH ;
REPINE, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2516-2520
[6]   HEAT-SHOCK RESPONSE IS ASSOCIATED WITH ENHANCED POSTISCHEMIC VENTRICULAR RECOVERY [J].
CURRIE, RW ;
KARMAZYN, M ;
KLOC, M ;
MAILER, K .
CIRCULATION RESEARCH, 1988, 63 (03) :543-549
[7]   TUMOR-NECROSIS-FACTOR-ALPHA PRETREATMENT IS PROTECTIVE IN A RAT MODEL OF MYOCARDIAL ISCHEMIA-REPERFUSION INJURY [J].
EDDY, LJ ;
GOEDDEL, DV ;
WONG, GHW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) :1056-1059
[8]  
FAHIMI HD, 1979, AM J PATHOL, V96, P373
[9]   Importance of the early alterations of energy metabolism in the induction and the disappearance of ischemic preconditioning in the isolated rat heart [J].
Garnier, A ;
Rossi, A ;
Lavanchy, N .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1996, 28 (08) :1671-1682
[10]  
JIE O, 1996, ALCOHOL CLIN EXP RES, V20, pA102