The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes

被引：47

作者：

Donohoe, Gary ^{[1
,2
,3
]}

Morris, Derek W. ^{[1
,2
]}

Corvin, Aiden ^{[1
,2
,3
]}

机构：

[1] St James Hosp, Neuropsychiat Genet Res Grp, Dept Psychiat, Trin Coll Dublin, Dublin 8, Ireland

[2] Univ Dublin Trinity Coll, Inst Mol Med, Dublin 2, Ireland

[3] Univ Dublin Trinity Coll, Trin Coll Inst Neurosci, Dublin 2, Ireland

来源：

SCHIZOPHRENIA BULLETIN | 2010年 / 36卷 / 05期

基金：

爱尔兰科学基金会;

关键词：

ZNF804A; schizophrenia; genetics; GENOME-WIDE ASSOCIATION; AUTISM SPECTRUM DISORDER; COMMON VARIANTS; SCHIZOPHRENIA; RISK; LOCI;

D O I：

10.1093/schbul/sbq080

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

As the first gene to have achieved genome-wide significance for psychosis, ZNF804A has predictably been a subject of intense research activity. We review the evidence to date for the association between schizophrenia and the original risk variant rs1344706 identified as well as additional common and rare variants at this locus. We describe the still scant literature on the biological function of ZNF804A and discuss the efforts being made to characterize and refine the associated phenotype using imaging and neuropsychological approaches. We conclude that ZNF804A is robustly, if modestly, associated with schizophrenia risk, with much work still remaining to elucidate its role in schizophrenia biology.

引用

页码：904 / 909

页数：6

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