The high-conductance state of neocortical neurons in vivo

被引:781
作者
Destexhe, A
Rudolph, M
Paré, D
机构
[1] CNRS, Integrat & Computat Neurosci Unit, F-91198 Gif Sur Yvette, France
[2] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrn1198
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intracellular recordings in vivo have shown that neocortical neurons are subjected to an intense synaptic bombardment in intact networks and are in a ' high- conductance' state. In vitro studies have shed light on the complex interplay between the active properties of dendrites and how they convey discrete synaptic inputs to the soma. Computational models have attempted to tie these results together and predicted that high- conductance states profoundly alter the integrative properties of cortical neurons, providing them with a number of computational advantages. Here, we summarize results from these different approaches, with the aim of understanding the integrative properties of neocortical neurons in the intact brain.
引用
收藏
页码:739 / 751
页数:13
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