Dipyridamole-loaded poly (L-latide) single crystals as drug delivery systems

被引：22

作者：

D'Ilario, Lucio ^{[1
]}

Francolini, Iolanda ^{[1
]}

Martinelli, Andrea ^{[1
]}

Piozzi, Antonella ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, Rome, Italy

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2007年 / 28卷 / 18-19期

关键词：

D O I：

10.1002/marc.200700224

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

POly(L-lactide) (PLLA) single crystals grown from dilute solution were employed for the first time in the preparation of drug delivery systems. PLLA single crystals were selectively hydrolyzed with HCl to provide the lamellar surface with carboxylic groups, which were employed to graft Dipyridamole (Dip), chosen as a model drug. The influence of the hydrolysis conditions on the single crystals properties was investigated by FT-IR, DSC and GPC measurements, while Dip grafting yield and drug release in lipase solution were followed by UV-vis spectroscopy. Dip was slowly delivered over a few days, suggesting the potential use of PLIA single crystals as controlled drug release carries for either oral or parenteral injection administration.

引用

页码：1900 / 1904

页数：5

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