学术探索
学术期刊
新闻热点
数据分析
智能评审

Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis

被引：70
作者：
Poole, AR
机构：
[1] Shriners Hosp Children, Joint Dis Lab, Montreal, PQ H3G 1A6, Canada
[2] McGill Univ, Dept Surg, Montreal, PQ H3A 2T5, Canada
[3] McGill Univ, Dept Med, Montreal, PQ, Canada
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2003年 / 29卷 / 04期
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
D O I：
10.1016/S0889-857X(03)00056-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article reviews new methodologies that are being developed for the detection of incident osteoarthritis (OA) and the progression of established OA. These tests are based mainly upon serum or urine assays of biomarkers that are products of defined tissue-specific molecular events related to joint damage. These biomarkers can now be detected by sensitive and specific immunoassays. Recent studies in animal models and in humans with knee OA have revealed that these tests are of value in detecting early OA and can discriminate between populations that differ with respect to the progression of joint damage. These assays may also be of value in clinical trials of disease-modifying OA drugs.
引用
收藏
页码：803 / +
页数：18
相关论文
共 75 条
  • [1] Aigner T, 1999, ARTHRITIS RHEUM, V42, P1443, DOI 10.1002/1529-0131(199907)42:7<1443::AID-ANR18>3.0.CO
  • [2] 2-A
  • [3] Gd-DTPA(2-) as a measure of cartilage degradation
    Bashir, A
    Gray, ML
    Burstein, D
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1996, 36 (05) : 665 - 673
  • [4] A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    Bathon, JM
    Martin, RW
    Fleischmann, RM
    Tesser, JR
    Schiff, MH
    Keystone, EC
    Genovese, MC
    Wasko, MC
    Moreland, LW
    Weaver, AL
    Markenson, J
    Finck, BK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (22) : 1586 - 1593
  • [5] Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
    Billinghurst, RC
    Dahlberg, L
    Ionescu, M
    Reiner, A
    Bourne, R
    Rorabeck, C
    Mitchell, P
    Hambor, J
    Diekmann, O
    Tschesche, H
    Chen, J
    VanWart, H
    Poole, AR
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (07) : 1534 - 1545
  • [6] CAMPION GV, 1989, BRIT J RHEUMATOL, V28, P393
  • [7] OSTEOARTHRITIS IN CYNOMOLGUS MACAQUES .2. DETECTION OF MODULATED PROTEOGLYCAN EPITOPES IN CARTILAGE AND SYNOVIAL-FLUID
    CARLSON, CS
    LOESER, RF
    JOHNSTONE, B
    TULLI, HM
    DOBSON, DB
    CATERSON, B
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 1995, 13 (03) : 399 - 409
  • [8] CEREJO R, 2002, ARTHRITIS RHEUM, V46, pS144
  • [9] Tissue inhibitor of metalloprotease-1 (TIMP-1) serum level may predict progression od hip osteoarthritis
    Chevalier, X
    Conrozier, T
    Gehrmann, M
    Claudepierre, P
    Mathieu, P
    Unger, S
    Vignon, E
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2001, 9 (04) : 300 - 307
  • [10] Collagen type IIC-telopeptide fragments as an index of cartilage degradation
    Christgau, S
    Garnero, P
    Fledelius, C
    Moniz, C
    Ensig, M
    Gineyts, E
    Rosenquist, C
    Qvist, P
    [J]. BONE, 2001, 29 (03) : 209 - 215
12345678