Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice

被引：169

作者：

Qamar, A ^{[1
]}

Aboudola, S ^{[1
]}

Warny, M ^{[1
]}

Michetti, P ^{[1
]}

Pothoulakis, C ^{[1
]}

LaMont, JT ^{[1
]}

Kelly, CP ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02215 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 04期

关键词：

D O I：

10.1128/IAI.69.4.2762-2765.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toroid A by gavage to S, boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii-mediated protection against diarrheal illnesses.

引用

页码：2762 / 2765

页数：4

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