Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation

被引：89

作者：

Bajada, S. ^{[1
]}

Harrison, P. E. ^{[1
]}

Ashton, B. A. ^{[1
]}

Cassar-Pullicino, V. N. ^{[1
]}

Ashammakhi, N. ^{[1
]}

Richardson, J. B. ^{[1
]}

机构：

[1] Robert Jones & Agnes Hunt Orthopaed Hosp, Oswestry SY10 7AG, Shrops, England

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2007年 / 89B卷 / 10期

关键词：

D O I：

10.1302/0301-620X.89B10.19103

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Successful healing of a nine-year tibial nonunion resistant to six previous surgical procedures was achieved by tissue engineering. We used autologous bone marrow stromal cells (BMSCs) expanded to 5 x 10(6) cells after three weeks' tissue culture. Calcium sulphate (CaSO4) in pellet form was combined with these cells at operation. The nonunion was clinically and radiologically healed two months after implantation. This is the description of on healing of a long-standing tibial nonunion by tissue engineering. The successful combination of BMSCs and CaSO4 has not to our knowledge been reported in a clinical setting.

引用

页码：1382 / 1386

页数：5

共 32 条

[1] Matrix regulation of skeletal cell apoptosis - Role of calcium and phosphate ions [J].

Adams, CS ;

Mansfield, K ;

Perlot, RL ;

Shapiro, IM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) :20316-20322

[2] The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects [J].

Bruder, SP ;

Kraus, KH ;

Goldberg, VM ;

Kadiyala, S .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1998, 80A (07) :985-996

[3] MESENCHYMAL STEM-CELLS [J].

CAPLAN, AI .

JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (05) :641-650

[4] Clinical use of marrow osteoprogenitor cells to stimulate osteogenesis [J].

Connolly, JF .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 1998, (355) :S257-S266

[5] Healing of segmental bone defects with granular porous hydroxyapatite augmented with recombinant human osteogenic protein-1 or autologous bone marrow [J].

den Boer, FC ;

Wippermann, BW ;

Blokhuis, TJ ;

Patka, P ;

Bakker, FC ;

Haarman, HJTM .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2003, 21 (03) :521-528

[6] ENHANCEMENT OF FRACTURE-HEALING [J].

EINHORN, TA .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1995, 77A (06) :940-956

[7]

FRIEDENS.AJ, 1966, J EMBRYOL EXP MORPH, V16, P381

[8] Percutaneous bone marrow grafting for the treatment of tibial non-union [J].

Goel, A ;

Sangwan, SS ;

Siwach, RC ;

Ali, AM .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2005, 36 (01) :203-206

[9]

HEALEY JH, 1990, CLIN ORTHOP RELAT R, P280

[10] The use of percutaneous autologous bone marrow transplantation in nonunion and avascular necrosis of bone [J].

Hernigou, P ;

Poignard, A ;

Manicom, O ;

Mathieu, G ;

Rouard, H .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2005, 87B (07) :896-902

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