microRNA and Cancer

被引:139
作者
Li, Mengfeng [1 ,2 ]
Li, Jun [1 ,3 ]
Ding, Xiaofan [1 ,3 ]
He, Mian [1 ,2 ]
Cheng, Shi-Yuan [4 ,5 ]
机构
[1] Sun Yat Sen Univ, Key Lab Trop Dis Control, Minist Educ, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Microbiol, Guangzhou 510080, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biochem, Guangzhou 510080, Guangdong, Peoples R China
[4] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15213 USA
[5] Univ Pittsburgh, Dept Pathol & Med, Pittsburgh, PA 15213 USA
来源
AAPS JOURNAL | 2010年 / 12卷 / 03期
基金
美国国家卫生研究院;
关键词
biomarker; cancer; drug discovery; drug target; microRNA; CHRONIC LYMPHOCYTIC-LEUKEMIA; DOWN-REGULATION; BREAST-CANCER; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; TRANSCRIPTIONAL ACTIVATION; TUMOR INVASION; GROWTH ARREST; FEEDBACK LOOP;
D O I
10.1208/s12248-010-9194-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
MicroRNAs (miRNAs), a class of small, regulatory, non-coding RNA molecules, display aberrant expression patterns and functional abnormalities in human diseases including cancers. This review summarizes the abnormally expressed miRNAs in various types of human cancers, possible mechanisms underlying such abnormalities, and miRNA-modulated molecular pathways critical for cancer development. Practical implications of miRNAs as biomarkers, novel drug targets and therapeutic tools for diagnosis, prognosis, and treatments of human cancers are also discussed.
引用
收藏
页码:309 / 317
页数:9
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