Select forms of tumor cell apoptosis induce dendritic cell maturation

被引:52
作者
Demaria, S
Santori, FR
Ng, B
Liebes, L
Formenti, SC
Vukmanovic, S
机构
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Med, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Radiat Oncol, New York, NY 10016 USA
[4] NYU, Sch Med, Inst Canc, New York, NY 10016 USA
[5] Childrens Natl Med Ctr, Ctr Canc & Immunol, Washington, DC 20010 USA
关键词
costimulation; tumor immunity; Fas/CD95; chemotherapy;
D O I
10.1189/jlb.0804478
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Dendritic cells (DC) play a crucial role in initiating immune responses to tumors. DC can efficiently present antigens from apoptotic tumor cells, but apoptotic cells are thought to lack the inflammatory signals required to induce DC maturation. Here, we show that apoptosis of 67NR mouse carcinoma cells via the Fas (CD95) pathway or induced by the anticancer drug hortezomib (PS341) but not by ultraviolet irradiation is associated with the production of maturation signals for DC. These data have important implications for the effects of chemotherapy on antitumor immunity in solid and hematologic malignancies.
引用
收藏
页码:361 / 368
页数:8
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