The pharmacodynamics of aminoglycosides

被引：169

作者：

Lacy, MK

Nicolau, DP

Nightingale, CH

Quintiliani, R

机构：

[1] Hartford Hosp, Off Res Adm, Hartford, CT 06102 USA

[2] Hartford Hosp, Div Infect Dis, Hartford, CT 06102 USA

[3] Univ Kansas, Med Ctr, Dept Pharm Practice, Kansas City, KS 66103 USA

来源：

CLINICAL INFECTIOUS DISEASES | 1998年 / 27卷 / 01期

关键词：

D O I：

10.1086/514620

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily aminoglycoside dosing regimens. This new approach to aminoglycoside dosing appears to be safe, efficacious, and cost-effective, resulting in its increasing popularity in clinical practice.

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收藏

页码：23 / 27

页数：5

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