Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)

被引：55

作者：

Watanabe, K

Morinaka, Y

Iseki, K

Watanabe, T

Yuki, S

Nishi, H

机构：

[1] Mitsubishi Pharma Corp, Res Lab 1, Div Res & Dev, Aoba Ku, Yokohama, Kanagawa 2270033, Japan

[2] Mitsubishi Pharma Corp, Res Lab 2, Pharmaceut Res Unit, Div Res & Dev,Aoba Ku, Yokohama, Kanagawa 2270033, Japan

[3] Mitsubishi Kagaku Med Inc, Tokyo, Japan

[4] Toray Industries Ltd, Pharmaceut Res Labs, Kanagawa, Japan

[5] Mitsubishi Pharma Corp, Sales & Mkt Unit, Integrated Mkt Unit, Mkt Dept 1, Osaka, Japan

[6] Mitsubishi Pharma Corp, Off President, Osaka, Japan

来源：

REDOX REPORT | 2003年 / 8卷 / 03期

关键词：

D O I：

10.1179/135100003225001520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.

引用

页码：151 / 155

页数：5

共 10 条

[1]

Adams HP, 1996, STROKE, V27, P1711

[2] ALPHA-PHENYL-TERT-BUTYL-NITRONE REDUCES CORTICAL INFARCT AND EDEMA IN RATS SUBJECTED TO FOCAL ISCHEMIA [J].