Solid-phase synthesis of a library of piperazinediones and diazepinediones via Kaiser oxime resin

被引：51

作者：

Smith, RA ^{[1
]}

Bobko, MA ^{[1
]}

Lee, W ^{[1
]}

机构：

[1] Bayer Corp, Div Pharmaceut, W Haven, CT 06516 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(98)00428-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A combinatorial library of piperazinediones has been prepared by automated parallel solid-phase synthesis. The five-step reaction protocol makes use of Kaiser oxime resin, to enable cleavage from the polymeric support concomitant with an intramolecular displacement reaction, under very mild conditions. The methodology was also successfully extended to the preparation of the seven-membered ring homologs, diazepinediones. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2369 / 2374

页数：6

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