Polydimethylsiloxanes in supercritical solvent impregnation (SSI) of polymers

被引：27

作者：

Alessi, P ^{[1
]}

Kikic, I

Cortesi, A

Fogar, A

Moneghini, M

机构：

[1] Univ Trieste, Dept Chem Environm & Raw Mat Engn, I-34127 Trieste, Italy

[2] Univ Trieste, Dept Pharmaceut Sci, I-34127 Trieste, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2003年 / 27卷 / 03期

关键词：

polydimethylsiloxanes; solubility; impregnation; supercritical fluids; pharmaceutical formulations;

D O I：

10.1016/S0896-8446(02)00267-X

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polydimethylsiloxanes (PDMS) are surfactants largely used at supercritical conditions for different applications. In this work PDMS with relatively low molecular weight have been used; their solubility in supercritical carbon dioxide at different conditions has been determined. They can be successfully used for increasing the solubility of some drugs in supercritical carbon dioxide. The use of PDMS for the production of controlled drug release products has been evaluated. (C) 2003 Published by Elsevier B.V.

引用

页码：309 / 315

页数：7

共 13 条

[1]

ALESSI P, 1998, P 5 M SUP FLUIDS NIC, V1, P373

[2]

ALESSI P, 2000, P 7 M SUP FLUIDS ANT, P933

[3] Supercritical fluids chromatography for impregnation optimization [J].

Cortesi, A ;

Alessi, P ;

Kikic, I ;

Kirchmayer, S ;

Vecchione, F .

JOURNAL OF SUPERCRITICAL FLUIDS, 2000, 19 (01) :61-68

[4]

Dollery C., 1999, THERAPEUTIC DRUGS

[5] Use of polydimethylsiloxane for endoscopic treatment of neurogenic urinary incontinence in children [J].

Guys, JM ;

Simeoni-Alias, J ;

Fakhro, A ;

Delarue, A .

JOURNAL OF UROLOGY, 1999, 162 (06) :2133-2135

[6] Interfacial activity of polymeric surfactants at the polystyrene carbon dioxide interface [J].

Harrison, KL ;

da Rocha, SRP ;

Yates, MZ ;

Johnston, KP ;

Canelas, D ;

DeSimone, JM .

LANGMUIR, 1998, 14 (24) :6855-6863

[7]

Kheir JN, 1998, J LONG-TERM EFF MED, V8, P55

[8]

LEGEAIS JM, 1997, P 1997 EUR MAT RES S, P1517

[9] Solubility of anti-inflammatory drugs in supercritical carbon dioxide [J].

Macnaughton, SJ ;

Kikic, I ;

Foster, NR ;

Alessi, P ;

Cortesi, A ;

Colombo, I .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 1996, 41 (05) :1083-1086

[10]

MEEKS RG, 1999, MED DEVICE DIAGN MAY, P112

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