Circadian rhythms: molecular basis of the clock

被引：68

作者：

Wilsbacher, LD

Takahashi, JS

机构：

[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[2] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(98)80017-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Much progress has been made during the past year in the molecular dissection of the circadian clock. Recently identified circadian genes in mouse, Drosophila, and cyanobacteria demonstrate the universal nature of negative feedback regulation as a circadian mechanism; furthermore, the mouse and Drosophila genes are structurally and functionally conserved. In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology.

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收藏

页码：595 / 602

页数：8

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