HLA/KIR Restraint of HIV: Surviving the Fittest

被引：114

作者：

Bashirova, Arman A. ^{[1
]}

Thomas, Rasmi

Carrington, Mary

机构：

[1] Massachusetts Gen Hosp, MIT, Ragon Inst, Boston, MA 02129 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 | 2011年 / 29卷

关键词：

CTL; escape mutations; NK cells; GWAS; host genetics; viral evolution; CYTOTOXIC T-LYMPHOCYTE; HLA CLASS-I; MHC CLASS-I; IMMUNODEFICIENCY-VIRUS-REPLICATION; CELL-RECEPTOR REPERTOIRES; NATURAL-KILLER-CELLS; NK-CELLS; MAJOR DETERMINANTS; PRIMARY INFECTION; IMMUNE-RESPONSES;

D O I：

10.1146/annurev-immunol-031210-101332

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more recently the killer cell immunoglobulin-like (KIR) locus has been implicated in differential responses to the virus. Genome-wide association studies have convincingly shown that the HLA class I locus is the most significant host genetic contributor to the variation in HIV control, underscoring a central role for CD8 T cells in resistance to the virus. However, both genetic and functional data indicate that part of the HLA effect on HIV is due to interactions between KIR and HLA genes, also implicating natural killer cells in defense against viral infection and viral expansion prior to initiation of an adaptive response. We review the HLA and KIR associations with HIV disease and the progress that has been made in understanding the mechanisms that explain these associations.

引用

页码：295 / 317

页数：23

共 152 条

[1] Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load [J].

Addo, MM ;

Yu, XG ;

Rathod, A ;

Cohen, D ;

Eldridge, RL ;

Strick, D ;

Johnston, MN ;

Corcoran, C ;

Wurcel, AG ;

Fitzpatrick, CA ;

Feeney, ME ;

Rodriguez, WR ;

Basgoz, N ;

Draenert, R ;

Stone, DR ;

Brander, C ;

Goulder, PJR ;

Rosenberg, ES ;

Altfeld, M ;

Walker, BD .

JOURNAL OF VIROLOGY, 2003, 77 (03) :2081-2092

[2] Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [J].

Allen, TM ;

Altfeld, M ;

Geer, SC ;

Kalife, ET ;

Moore, C ;

O'Sullivan, KM ;

DeSouza, I ;

Feeney, ME ;

Eldridge, RL ;

Maier, EL ;

Kaufmann, DE ;

Lahaie, MP ;

Reyor, L ;

Tanzi, G ;

Johnston, MN ;

Brander, C ;

Draenert, R ;

Rockstroh, JK ;

Jessen, H ;

Rosenberg, ES ;

Mallal, SA ;

Walker, BD .

JOURNAL OF VIROLOGY, 2005, 79 (21) :13239-13249

[3] Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection [J].

Allen, TM ;

Altfeld, M ;

Yu, XG ;

O'Sullivan, KM ;

Lichterfeld, M ;

Le Gall, S ;

John, M ;

Mothe, BR ;

Lee, PK ;

Kalife, ET ;

Cohen, DE ;

Freedberg, KA ;

Strick, DA ;

Johnston, MN ;

Sette, A ;

Rosenberg, ES ;

Mallal, SA ;

Goulder, PJR ;

Brander, C ;

Walker, BD .

JOURNAL OF VIROLOGY, 2004, 78 (13) :7069-7078

[4] Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection [J].

Alter, G ;

Teigen, N ;

T Davis, B ;

Addo, MM ;

Suscovich, TJ ;

Waring, MT ;

Streeck, H ;

Johnston, MN ;

Staller, KD ;

Zaman, MT ;

Yu, XG ;

Lichterfeld, M ;

Basgoz, N ;

Rosenberg, ES ;

Altfeld, M .

BLOOD, 2005, 106 (10) :3366-3369

[5] Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes [J].

Alter, Galit ;

Martin, Maureen P. ;

Teigen, Nickolas ;

Carr, William H. ;

Suscovich, Todd J. ;

Schneidewind, Arne ;

Streeck, Hendrik ;

Waring, Michael ;

Meier, Angela ;

Brander, Christian ;

Lifson, Jeffrey D. ;

Allen, Todd M. ;

Carrington, Mary ;

Altfeld, Marcus .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) :3027-3036

[6] Evolution of innate and adaptive effector cell functions during acute HIV-1 infection [J].

Alter, Galit ;

Teigen, Nickolas ;

Ahern, Ryan ;

Streeck, Hendrik ;

Meier, Angela ;

Rosenberg, Eric S. ;

Altfeld, Marcus .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (10) :1452-1460

[7] HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection [J].

Alter, Galit ;

Rihn, Suzannah ;

Walter, Katharine ;

Nolting, Anne ;

Martin, Maureen ;

Rosenberg, Eric S. ;

Miller, Jeffrey S. ;

Carrington, Mary ;

Altfeld, Marcus .

JOURNAL OF VIROLOGY, 2009, 83 (13) :6798-6805

[8] Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection [J].

Altfeld, M ;

Addo, MA ;

Rosenberg, ES ;

Hecht, FA ;

Lee, PK ;

Vogel, M ;

Yu, XG ;

Draenert, R ;

Johnston, MN ;

Strick, D ;

Allen, TA ;

Feeney, ME ;

Kahn, JO ;

Sekaly, RP ;

Levy, JA ;

Rockstroh, JK ;

Goulder, PJR ;

Walker, BD .

AIDS, 2003, 17 (18) :2581-2591

[9] HLA alleles associated with delayed progression to AIDS contribute strongly to the initial CD8+ T cell response against HIV-1 [J].

Altfeld, Marcus ;

Kalife, Elizabeth T. ;

Qi, Ying ;

Streeck, Hendrik ;

Lichterfeld, Mathias ;

Johnston, Mary N. ;

Burgett, Nicole ;

Swartz, Martha E. ;

Yang, Amy ;

Alter, Galit ;

Yu, Xu G. ;

Meier, Angela ;

Rockstroh, Juergen K. ;

Allen, Todd M. ;

Jessen, Heiko ;

Rosenberg, Eric S. ;

Carrington, Mary ;

Walker, Bruce D. .

PLOS MEDICINE, 2006, 3 (10) :1851-1864

[10] Characterization of CD4+ CTLs ex vivo [J].

Appay, V ;

Zaunders, JJ ;

Papagno, L ;

Sutton, J ;

Jaramillo, A ;

Waters, A ;

Easterbrook, P ;

Grey, P ;

Smith, D ;

McMichael, AJ ;

Cooper, DA ;

Rowland-Jones, SL ;

Kelleher, AD .

JOURNAL OF IMMUNOLOGY, 2002, 168 (11) :5954-5958

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