mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors

被引：82

作者：

De Rossi, E ^{[1
]}

Branzoni, M ^{[1
]}

Cantoni, R ^{[1
]}

Milano, A ^{[1
]}

Riccardi, G ^{[1
]}

Ciferri, O ^{[1
]}

机构：

[1] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

来源：

JOURNAL OF BACTERIOLOGY | 1998年 / 180卷 / 22期

关键词：

D O I：

10.1128/JB.180.22.6068-6071.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [H-3]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.

引用

页码：6068 / 6071

页数：4

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