Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe1)nociceptin(1-13)NH2

被引：16

作者：

Bytner, B ^{[1
]}

Huang, YH

Yu, LC

Lundeberg, T

Nylander, I

Rosen, A

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[2] Peking Univ, Coll Life Sci, Dept Physiol, Beijing 100872, Peoples R China

[3] Karolinska Inst, Dept Surg Sci, Stockholm, Sweden

[4] Huddinge Hosp, Karolinska Inst, Dept Odontol, S-14186 Huddinge, Sweden

[5] Dept Pharmaceut Biosci, S-75124 Uppsala, Sweden

来源：

BRAIN RESEARCH | 2001年 / 922卷 / 01期

关键词：

nociceptin; nociceptin antagonist; nociception; ORL-1; receptor; periaqueductal grey;

D O I：

10.1016/S0006-8993(01)03161-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigated the effect of intraperiaqueductal grey injection of nociceptin/orphanin FQ (N/OFQ) and an antagonist (Nphe(i))nociceptin(1-13)NH2 on the hindpaw withdrawal response to thermal and mechanical stimulation in rats. N/OFQ (5 nmol) significantly decreased the nociceptive thresholds in both tests and 1, 5 and 10 nmol of (Nphe(i))nociceptin(1-13)NH2 significantly reversed this effect in a dose dependent way. Our results demonstrate, that N/OFQ has a nociceptive action, possibly through inhibition of PAG neurons. This effect is blocked by the antagonist (Nphe(i))nociceptin(1-13)NH2 probably via ORL1 receptors in the periaqueductal grey. (C) 2001 Elsevier Science BY. All rights reserved.

引用

页码：118 / 124

页数：7

共 33 条

[1] ENDOGENOUS PAIN CONTROL-SYSTEMS - BRAIN-STEM SPINAL PATHWAYS AND ENDORPHIN CIRCUITRY [J].

BASBAUM, AI ;

FIELDS, HL .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :309-338

[2] Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist [J].

Calo', G ;

Guerrini, R ;

Bigoni, R ;

Rizzi, A ;

Marzola, G ;

Okawa, H ;

Bianchi, C ;

Lambert, DG ;

Salvadori, S ;

Regoli, D .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (06) :1183-1193

[3] The orphanin FQ system: an emerging target for the management of pain? [J].

Darland, T ;

Grandy, DK .

BRITISH JOURNAL OF ANAESTHESIA, 1998, 81 (01) :29-37

[4] Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more [J].

Darland, T ;

Heinricher, MM ;

Grandy, DK .

TRENDS IN NEUROSCIENCES, 1998, 21 (05) :215-221

[5] Orphanin FQ, a novel neuropeptide with anti-stress-like activity [J].

Griebel, G ;

Perrault, G ;

Sanger, DJ .

BRAIN RESEARCH, 1999, 836 (1-2) :221-224

[6]

HAMON M, 1998, NS ARCH PHARM S2, V358

[7] Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor [J].

Hashimoto, Y ;

Caló, G ;

Guerrini, R ;

Smith, G ;

Lambert, DG .

NEUROSCIENCE LETTERS, 2000, 278 (1-2) :109-112

[8] Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress [J].

Jenck, F ;

Moreau, JL ;

Martin, JR ;

Kilpatrick, GJ ;

Reinscheid, RK ;

Monsma, FJ ;

Nothacker, HP ;

Civelli, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14854-14858

[9]

LOVICK TA, 1991, NEWS PHYSIOL SCI, V6, P82

[10] Blockade of μ-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test [J].

Lutfy, K ;

Maidment, NT .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (08) :1684-1688

← 1 2 3 4 →