Sonic hedgehog: Making the gradient

被引：8

作者：

Bumcrot, DA

McMahon, AP

机构：

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1074-5521(96)90077-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecule, which nevertheless seems to provide a developmental signal that acts at a distance and has different effects depending on its concentration. Recent structural data suggest that zinc-dependent proteolysis may somehow be involved in Sonic hedgehog's function.

引用

页码：13 / 16

页数：4

共 23 条

[1]

BUMCROT DA, 1995, MOL CELL BIOL, V15, P2294

[2] PATTERNING OF MAMMALIAN SOMITES BY SURFACE ECTODERM AND NOTOCHORD - EVIDENCE FOR SCLEROTOME INDUCTION BY A HEDGEHOG HOMOLOG [J].