Role of the two-component signal transduction and the phosphoenolpyruvate:carbohydrate phosphotransferase systems in competence development of Haemophilus influenzae Rd

被引：13

作者：

Gwinn, ML

Yi, D

Smith, O

Tomb, JF

机构：

[1] Department of Molecular Biology, Johns Hopkins University, School of Medicine, Baltimore

[2] Johns Hopkins University, School of Medicine, Baltimore, MD, 505 PCTB

[3] Institute for Genomic Research, Rockville

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 21期

关键词：

D O I：

10.1128/jb.178.21.6366-6368.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Haemophilus influenzae Rd becomes competent for transformation by nutritional downshift or transient anaerobic growth through a process that requires cyclic AMP receptor protein and adenylate cyclase. Insertion mutations in crr or ptsI of the phosphoenolpyruvate:carbohydrate phosphotransferase system lowered transformation frequencies, and the effect was reversed by the addition of cyclic AMP. However, insertions into H. influenzae homologs of two-component signal transduction genes had no effect on competence.

引用

收藏

页码：6366 / 6368

页数：3

相关论文

共 21 条

[1]

BARCAK GJ, 1991, METHOD ENZYMOL, V204, P321

[2] CYCLIC-AMP IN PROKARYOTES [J].

BOTSFORD, JL ;

HARMAN, JG .

MICROBIOLOGICAL REVIEWS, 1992, 56 (01) :100-122

[3] THE GENE ENCODING CAMP RECEPTOR PROTEIN IS REQUIRED FOR COMPETENCE DEVELOPMENT IN HAEMOPHILUS-INFLUENZAE RD [J].

CHANDLER, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1626-1630

[4] Characterization of the Haemophilus influenzae topA locus: DNA topoisomerase I is required for genetic competence [J].

Chandler, MS ;

Smith, RA .

GENE, 1996, 169 (01) :25-31

[5] THE CPX 2-COMPONENT SIGNAL-TRANSDUCTION PATHWAY OF ESCHERICHIA-COLI REGULATES TRANSCRIPTION OF THE GENE SPECIFYING THE STRESS-INDUCIBLE PERIPLASMIC PROTEASE, DEGP [J].

DANESE, PN ;

SNYDER, WB ;

COSMA, CL ;

DAVIS, LJB ;

SILHAVY, TJ .

GENES & DEVELOPMENT, 1995, 9 (04) :387-398

[6] THE HAEMOPHILUS-INFLUENZAE ADENYLATE-CYCLASE GENE - CLONING, SEQUENCE, AND ESSENTIAL ROLE IN COMPETENCE [J].

DOROCICZ, IR ;

WILLIAMS, PM ;

REDFIELD, RJ .

JOURNAL OF BACTERIOLOGY, 1993, 175 (22) :7142-7149

[7] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

[8] STUDIES ON TRANSFORMATIONS OF HEMOPHILUS INFLUENZAE .1. COMPETENCE [J].

GOODGAL, SH ;

HERRIOTT, RM .

JOURNAL OF GENERAL PHYSIOLOGY, 1961, 44 (06) :1201-&

[9] DEFINED NONGROWTH MEDIA FOR STAGE-II DEVELOPMENT OF COMPETENCE IN HAEMOPHILUS-INFLUENZAE [J].

HERRIOTT, RM ;

MEYER, EM ;

VOGT, M .

JOURNAL OF BACTERIOLOGY, 1970, 101 (02) :517-&

[10] Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system [J].

Macfadyen, LP ;

Dorocicz, IR ;

Reizer, J ;

Saier, MH ;

Redfield, RJ .

MOLECULAR MICROBIOLOGY, 1996, 21 (05) :941-952