Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester

被引：57

作者：

Gualandi, Chiara ^{[2
,3
]}

White, Lisa J. ^{[4
]}

Chen, Liu ^{[5
]}

Gross, Richard A. ^{[5
]}

Shakesheff, Kevin M. ^{[4
]}

Howdle, Steven M. ^{[1
]}

Scandola, Mariastella ^{[2
,3
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[3] Univ Bologna, INSTM UdR Bologna, I-40126 Bologna, Italy

[4] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[5] NYU, Polytech Inst, NSF I UCRC Biocatalysis & Bioproc Macromol, Brooklyn, NY 11201 USA

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

Supercritical CO2; Scaffold; Foaming; Biomaterial; Tissue engineering; OMEGA-PENTADECALACTONE; EPSILON-CAPROLACTONE; DRUG-DELIVERY; POLYMERS; BONE; CO2; TEMPERATURE; COMPOSITES; PRESSURE; SYSTEMS;

D O I：

10.1016/j.actbio.2009.07.020

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Porous scaffolds of a random co-polymer of omega-pentadecalactone (PDL) and epsilon-caprolactone (CL) (poly(PDL-CL)), synthesized by biocatalysis, were fabricated by supercritical carbon dioxide (scCO(2)) foaming. The co-polymer, containing 31 mol.% CL units, is highly crystalline (T-m = 82 degrees C, Delta H-m = 105 J g(-1)) thanks to the ability of the two monomer units to co-crystallize. The co-polymer can be successfully foamed upon homogeneous absorption of scCO(2) at T > T-m. The effect of soaking time, depressurization rate and cooling rate on scaffold porosity, pore size distribution and pore interconnectivity was investigated by micro X-ray computed tomography. Scaffolds with a porosity in the range 42-76% and an average pore size of 100-375 mu m were successfully obtained by adjusting the main foaming parameters. Process conditions in the range investigated did not affect the degree of crystallinity of poly(PDL-CL) scaffolds. A preliminary study of the mechanical properties of the scaffolds revealed that poly(PDL-CL) foams may find application in the regeneration of cartilage tissue. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：130 / 136

页数：7

共 32 条

[1]

Preparation and characterization of microcellular polystyrene foams processed in supercritical carbon dioxide [J].