Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis-Specific Gamma Interferon Response in Vaccinated Infants

被引：23

作者：

Dirix, V. ^{[1
]}

Verscheure, V. ^{[1
]}

Goetghebuer, T. ^{[3
]}

Hainaut, M. ^{[3
]}

Debrie, A. S. ^{[4
,5
]}

Locht, C. ^{[4
,5
]}

Mascart, F. ^{[1
,2
]}

机构：

[1] Univ Libre Bruxelles, Hop Erasme, Lab Vaccinol & Mucosal Immun, Brussels, Belgium

[2] Univ Libre Bruxelles, Hop Erasme, Immunobiol Clin, Brussels, Belgium

[3] Univ Libre Bruxelles, Hop St Pierre, Dept Pediat, Brussels, Belgium

[4] INSERM, U629, F-59019 Lille, France

[5] Inst Pasteur, F-59019 Lille, France

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2009年 / 16卷 / 12期

关键词：

CELL-MEDIATED-IMMUNITY; RESPIRATORY-INFECTION; WHOLE-CELL; FILAMENTOUS HEMAGGLUTININ; T-CELLS; TYPE-1; POLYMORPHISM; INDUCTION; TOXIN; PROMOTER;

D O I：

10.1128/CVI.00314-09

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-specific gamma interferon (IFN-gamma) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-gamma after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-gamma levels between individuals. We show here that the inhibition of the specific IFN-gamma response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions -1082, -819, and -592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.

引用

页码：1816 / 1821

页数：6

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