Parallel chemistry investigations of ortho-directed hydrogen isotope exchange between substituted aromatics and isotopic water:: novel catalysis by cyclooctadienyliridium(I)pentan-1,3-dionates

被引：33

作者：

Kingston, LP ^{[1
]}

Lockley, WJS ^{[1
]}

Mather, AN ^{[1
]}

Spink, E ^{[1
]}

Thompson, SP ^{[1
]}

Wilkinson, DJ ^{[1
]}

机构：

[1] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 15期

关键词：

iridium catalysts; complexes; exchange; deuterium; labelling; metalation; diones;

D O I：

10.1016/S0040-4039(00)00244-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel iridium-based catalysts which promote ortho-directed hydrogen isotope exchange between substituted aromatics and isotopic water have been identified via a combination of screening and subsequent ligand optimisation. The catalysts are more active, operate at lower temperature and are applicable to a wider variety of substrates than previously known systems. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2705 / 2708

页数：4

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