A rat model of Parkinsonism shows depletion of dopamine in the retina

被引：29

作者：

Biehlmaier, Oliver

Alam, Mesbah

Schmidt, Werner J.

机构：

[1] Univ Zurich, Swiss Fed Inst Technol, ETH Zurich, Dept Biol, CH-8057 Zurich, Switzerland

[2] Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland

[3] Univ Tubingen, Fac Biol, Inst Zool, D-72076 Tubingen, Germany

来源：

NEUROCHEMISTRY INTERNATIONAL | 2007年 / 50卷 / 01期

关键词：

rotenone; animal models; neurodegeneration; amacrine cells; Parkinson disease;

D O I：

10.1016/j.neuint.2006.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retinal dopamine (DA) deficiency is an important feature of the pathogenesis in Parkinson's disease (PD) visual dysfunction. Systemic inhibition of complex] (rotenone) in rats has been proposed as a model of PD. In this study, we investigated whether systemic inhibition of complex I can induce impairment of DA-ergic cells in the retina, similar to the destruction of retinal cells found in PD patients. Rotenone (2.5 mg/kg i.p., daily) was administered over 60 days. Neurochemically, rotenone treated rats showed a depletion of DA in the striatum and substantia nigra SN). In addition, the number of retinal DA-ergic amacrine cells was significantly reduced in the rotenone treated animals. This study is the first one giving highlight towards a deeper understanding of systemic complex I inhibition (rotenone as an environmental toxin) and the connection between both, DA-ergic degeneration in the nigrostriatal pathway, and in the DA-ergic amacrine cells of the retina. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：189 / 195

页数：7

共 35 条

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