p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1

被引：52

作者：

Saito, A

Furukawa, T

Fukushige, S

Koyama, S

Hoshi, M

Hayashi, Y

Horii, A

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Dept Pediat Oncol, Sendai, Miyagi 980, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 03期

关键词：

ING1; p33; alternative splicing; p24/ING1-ALT1; p47/ING1-ALT2; chromosome band 13q34;

D O I：

10.1007/s100380050206

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

p33/ING1s (the growth inhibitor ING1 and candidate tumor suppressor ING1) are key players in the suppressive pathways for human tumorigenesis. We analyzed their complete transcripts, primary structures, and expression. The results led us to discover two novel and related alternatively spliced transcripts encoding p24/ING1-ALT1 and p47/ING1-ALT2. They share C-terminal residues with the candidate tumor suppressors p33/ING1. The candidate tumor suppressors p33/ING1 and p24/ING1-ALT1 were coexpressed in a variety of fetal and adult human tissues, but p47/ING1-ALT2 was minimally expressed.

引用

页码：177 / 181

页数：5

共 10 条

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