Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

被引：59

作者：

Beseda, Igor ^{[1
]}

Czollner, Laszlo ^{[1
]}

Shah, Priti S. ^{[2
]}

Khunt, Rupesh ^{[1
]}

Gaware, Rawindra ^{[1
]}

Kosma, Paul ^{[3
]}

Stanetty, Christian ^{[3
]}

del Ruiz-Ruiz, Maria Carmen ^{[3
]}

Amer, Hassan ^{[3
]}

Mereiter, Kurt ^{[4
]}

Da Cunha, Thierry ^{[5
]}

Odermatt, Alex ^{[5
]}

Classen-Houben, Dirk ^{[6
]}

Jordis, Ulrich ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Saurashtra Univ, Rajkot 360005, Gujarat, India

[3] Univ Nat Resources & Life Sci, Dept Chem, A-1190 Vienna, Austria

[4] Vienna Univ Technol, Inst Chem Technol & Analyt, A-1060 Vienna, Austria

[5] Univ Basel, Pharmactr, Div Mol & Syst Toxicol, CH-4056 Basel, Switzerland

[6] Onepharm Res & Dev, A-1210 Vienna, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Hydroxysteroid dehydrogenase (HSD); X-ray; Metabolic diseases; 11; beta-HSD1; beta-HSD2; Inhibitors; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; APPARENT MINERALOCORTICOID EXCESS; 18-BETA-GLYCYRRHETINIC ACID; REDUCTASE-ACTIVITY; INHIBITORS; HYPERTENSION; POTENT; MICE; RAT; TRANSFORMATIONS;

D O I：

10.1016/j.bmc.2009.10.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) was investigated. Novel compounds with modi. cations at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：433 / 454

页数：22

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