Caspase 8: The killer you can't live without

被引：14

作者：

Juin, P ^{[1
]}

Evan, G ^{[1
]}

机构：

[1] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74966

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proto-oncogene MYCN, a regulator of cell proliferation and cell death, is amplified in aggressive neuroblastomas, whereas expression of the apoptotic effector caspase 8 is suppressed. Understanding why this nervous system tumor should choose to up or down regulate these particular apoptotic factors may provide important information about oncogenesis and indicate new strategies for the treatment of neuroblastoma (pages 529-535).

引用

页码：498 / 500

页数：3

共 11 条

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