Genetic analysis of the circadian system in Drosophila melanogaster and mammals

被引:177
作者
Stanewsky, R [1 ]
机构
[1] Univ Regensburg, Inst Zool, Lehrstuhl Entwicklungsbiol, D-93040 Regensburg, Germany
来源
JOURNAL OF NEUROBIOLOGY | 2003年 / 54卷 / 01期
关键词
Drosophila melanogaster; circadian time deeping; genetic analysis;
D O I
10.1002/neu.10164
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:111 / 147
页数:37
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