Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone

被引：14

作者：

Hartwig, Jan ^{[1
,2
]}

Kirschning, Andreas ^{[1
,2
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, Schneiderberg 1B, D-30167 Hannover, Germany

[2] Leibniz Univ Hannover, Biomol Wirkstoffzentrum BMWZ, Schneiderberg 1B, D-30167 Hannover, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 09期

关键词：

flow synthesis; high temperature; industrial chemistry; synthetic methods; medicinal chemistry; FLASH VACUUM PYROLYSIS; SUPERCRITICAL WATER; ORGANIC-SYNTHESIS; CHEMISTRY; OPPORTUNITIES; YLIDES; ACID;

D O I：

10.1002/chem.201504409

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inductively heated steel reactors continuously perform organic transformations in water under high temperature conditions, utilizing the unique physiochemical properties of water at subcritical conditions. We demonstrated the power of this set-up in the continuous synthesis of the atypical antipsychotic drug iloperidone, in which we performed four out of five steps under aqueous conditions.

引用

收藏

页码：3044 / 3052

页数：9

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