Reversing Epigenetic Alterations Caused by Alcohol: A Promising Therapeutic Direction for Alcoholic Liver Disease

被引：17

作者：

Lin, Xiu-Xian ^{[1
,2
]}

Lian, Guang-Hui ^{[3
]}

Peng, Shi-Fang ^{[4
]}

Zhao, Qing ^{[1
,2
]}

Xu, Ying ^{[1
,2
]}

Ou-Yang, Dong-Sheng ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Chen, Yao ^{[1
,2
]}

机构：

[1] Cent S Univ, Dept Clin Pharmacol, Xiangya Hosp, Changsha 410078, Hunan, Peoples R China

[2] Cent S Univ, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Dept Gastroenterol, Xiangya Hosp, Changsha, Hunan, Peoples R China

[4] Cent S Univ, Dept Hepatol & Infect Dis, Xiangya Hosp, Changsha, Hunan, Peoples R China

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2018年 / 42卷 / 10期

关键词：

Alcoholic Liver Disease; Epigenetic Alteration; DNA Methylation; Histone Modification; MicroRNA; HEPATIC STELLATE CELLS; HISTONE H3 PHOSPHORYLATION; FATTY LIVER; SIRTUIN; EXTRACELLULAR VESICLES; CIRCULATING MICRORNAS; PROTECTIVE ACTION; DNA METHYLATION; GENE-EXPRESSION; DOWN-REGULATION;

D O I：

10.1111/acer.13863

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

100404 [儿少卫生与妇幼保健学];

摘要：

Alcoholic liver disease (ALD), a liver function disorder caused by excessive alcohol intake, is a serious threat to global public health and social development. Toxic metabolites and reactive oxygen species produced during the metabolism of alcohol can alter the epigenetic state including DNA methylation, histone modifications, and expression of microRNAs. Epigenetic alterations can conversely involve various signaling pathways, which could contribute to the initiation and progression of ALD. To elucidate the relationship between epigenetic alterations and alcohol damage not only reinforces our understanding on pathogenesis of ALD, but also provides novel targets for clinical diagnosis, treatment, and drug research of ALD. In this review, we have summarized the research progress of epigenetic alterations and related mechanisms caused by alcohol in the pathogenesis of ALD. Considering the invertibility of epigenetic alterations, treatment of ALD through epigenetic modification with common less harmful compounds is also related.

引用

页码：1863 / 1873

页数：11

共 102 条

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