Noradrenergic system interacts with genital reflexes induced by cocaine in paradoxical sleep-deprived male rats

被引:7
作者
Andersen, ML [1 ]
Antunes, IB [1 ]
Tufik, S [1 ]
机构
[1] Univ Fed Sao Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 Sao Paulo, Brazil
关键词
sleep deprivation; genital reflexes; cocaine; noradrenergic system; alpha and beta receptors;
D O I
10.1037/0735-7044.119.2.473
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Different doses of alpha-1, alpha-2, beta-1, and beta-2 adrenoceptor agonists or antagonists were administered to paradoxical sleep-deprived (PSD) rats prior to cocaine administration. Metboxamine reduced the percentage of rats displaying erection, whereas prazosin did not. Yohimbine significantly decreased this percentage. For beta-1 adrenoceptor drugs, both compounds reduced the percentage of rats displaying erection at the highest dose; beta-2 adrenoceptor drugs had no effect. Except for clonidine, all drugs significantly reduced the frequency of erection. Ejaculation was significantly decreased following yohimbine and beta-1 drugs, whereas it was completely abolished by prazosin. The results showed that noradrenergic drugs inhibited genital reflexes in PSD rats, with distinct responses in relation to their respective action over the adrenoceptor.
引用
收藏
页码:473 / 482
页数:10
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