Hyperbaric oxygen preconditioning protects lung against hyperoxic acute lung injury in rats via heme oxygenase-1 induction

被引：29

作者：

Feng, Ying ^{[1
]}

Zhang, Zinan ^{[1
]}

Li, Qiang ^{[2
]}

Li, Weihao ^{[1
]}

Xu, Jing ^{[1
]}

Cao, Huifang ^{[1
]}

机构：

[1] Fudan Univ, Huashan Hosp, Jingan Branch, Dept Resp Dis,Jingan Dist Ctr Hosp Shanghai, Shanghai 200040, Peoples R China

[2] Second Mil Med Univ, ChangHai Hosp, Dept Resp Dis, Shanghai 200433, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 456卷 / 02期

关键词：

Hyperoxic acute lung injury; Oxidative stress; Hyperbaric oxygen preconditioning; Heme oxygenase-1; ISCHEMIA-REPERFUSION INJURY; SPINAL-CORD ISCHEMIA; ANTIOXIDANT ENZYMES; EARLY APOPTOSIS; IN-VIVO; EXPRESSION; TOLERANCE; CELLS; MECHANISMS; TOURNIQUET;

D O I：

10.1016/j.bbrc.2014.09.074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hyperoxic acute lung injury (HALI) is a clinical syndrome as a result of prolonged supplement of high concentrations of oxygen. Previous studies have shown hyperbaric oxygen preconditioning (HBO-PC) had a protective effect on oxidative injury. In the present study, we investigated the effect of HBO-PC on HALI in rats. The results demonstrated that HBO-PC ameliorated the lung biochemical and histological alterations induced by hyperoxia, decreased oxidative products but increased antioxidant enzymes. Furthermore, HBO-PC up-regulated home oxygenase-1 (HO-1) mRNA and activity in lung tissues. The administration of HO-1 inhibitor, Zinc protoporphyrin IX, abolished its protective effects. The data showed that HBO-PC could protect rats against HALI and the anti-oxidative effect may be related to the up-regulation of HO-1. (C) 2014 Published by Elsevier Inc.

引用

页码：549 / 554

页数：6

共 36 条

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