Biology of Anti-Angiogenic Therapy-Induced Thrombotic Microangiopathy

被引：35

作者：

Eremina, Vera ^{[1
]}

Quaggin, Susan E. ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5T 3L9, Canada

[2] Univ Toronto, St Michaels Hosp, Div Nephrol, Toronto, ON M5B 1W8, Canada

[3] Univ Toronto, Dept Med, Univ Hlth Network, Toronto, ON, Canada

来源：

SEMINARS IN NEPHROLOGY | 2010年 / 30卷 / 06期

基金：

加拿大健康研究院;

关键词：

Anti-VEGF therapy; TMA; glomerulus; endothelial cells; ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; PHASE-III TRIAL; VASCULAR ENDOTHELIUM; TUMOR ANGIOGENESIS; SPLICE VARIANT; BREAST-CANCER; VEGF THERAPY; BEVACIZUMAB; PREECLAMPSIA;

D O I：

10.1016/j.semnephrol.2010.09.006

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Anti-vascular endothelial growth factor (VEGF) agents are an important component in the treatment of many solid tumors. As the indications for these targeted therapies grow, the expected number of patients to receive these drugs will increase exponentially. Despite the great promise, serious toxicities may arise. Here, we discuss the incidence, pathogenesis, and management of proteinuria and renal insufficiency associated with this class of drugs. © 2010 Elsevier Inc.

引用

页码：582 / 590

页数：9

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