Classification of acute leukemias

被引：38

作者：

Brunning, RD ^{[1
]}

机构：

[1] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

来源：

SEMINARS IN DIAGNOSTIC PATHOLOGY | 2003年 / 20卷 / 03期

关键词：

acute leukemia; lymphoblastic lymphoma; genetic abnormalities;

D O I：

10.1016/S0740-2570(03)00031-5

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Because of the increasing recognition of the importance of genetic events to the diagnosis and treatment of the acute leukemias, the proposed new World Health Organization (WHO) classification incorporates genetic aberrations and immunology as major defining features in addition to morphology. In a hierarchal approach, genetic changes have precedence in the acute myeloid leukemias and immunology and genetic changes have precedence in the acute lymphoblastic leukemias. Four major groups of acute myeloid leukemia are recognized: 1) Acute myeloid leukemias with recurrent genetic abnormalities, 2) Acute myeloid leukemia with multilineage dysplasia, 3) Acute myeloid leukemias, therapy related, and 4) Acute myeloid leukemia not otherwise categorized. Two types of acute lymphoblastic leukemia are recognized based on immunologic characteristics: precursor B lymphoblastic leukemia/lymphoma and precursor T lymphoblastic leukemia/lymphoma. Precursor B acute lymphoblastic leukemia/lymphoma is subclassified into prognostic genetic groups. Biphenotypic leukemia is recognized as a form of acute leukemia of ambiguous lineage. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：142 / 153

页数：12

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