Crellastatin A:: A cytotoxic bis-steroid sulfate from the vanuatu marine sponge Crella sp.

被引：25

作者：

D'Auria, MV

Giannini, C

Zampella, A

Minale, L

Debitus, C

Roussakis, C

机构：

[1] Univ Naples, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] ORSTOM, Ctr Noumea, Noumea, New Caledonia

[3] Univ Nantes, Fac Pharm, Inst Subst & Organismes Mer, F-44035 Nantes 01, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 21期

关键词：

D O I：

10.1021/jo981022v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new nonsymmetric dimeric steroid, crellastatin A (1), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochemistry of 1 was established from an analysis of ROESY experiments and from molecular mechanics and dynamics calculations. Crellastatin A (1), which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-NG cells (IC50 of 1.5 mu g/mL).

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页码：7382 / 7388

页数：7

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