On the reactivity of ascomycin at the binding domain.: Part 1:: Liberation of the tricarbonyl portion of ascomycin

被引：5

作者：

Baumann, K ^{[1
]}

Bacher, M ^{[1
]}

Damont, A ^{[1
]}

Högenauer, K ^{[1
]}

Steck, A ^{[1
]}

机构：

[1] Novartis Res Inst Vienna, Dept Med Chem, A-1235 Vienna, Austria

来源：

TETRAHEDRON | 2003年 / 59卷 / 50期

关键词：

ascomycin; binding domain; tricarbonyl portion;

D O I：

10.1016/j.tet.2003.10.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. Herein, methodologies, allowing the liberation of the tricarbonyl unit by blocking the 14-hydroxy group are reported. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：10075 / 10087

页数：13

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