Pyrrolo[2,3-h]quinolinones:: synthesis and photochemotherapic activity

被引：37

作者：

Barraja, P

Diana, P

Lauria, A

Montalbano, A

Almerico, AM

Dattolo, G

Cirrincione, G

Viola, G

Dall'Acqua, F

机构：

[1] Univ Palermo, Dipartimento Farmacochim Tossicol & Biol, I-90123 Palermo, Italy

[2] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(03)00529-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2809 / 2811

页数：3

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